Zverev needed treatment on his left hamstring in the second set and was clearly hampered as his close friend Thiem put him through the wringer with his trademark groundstrokes.
Images from Day 6 of the French Open in Paris on Friday.
Djokovic received severe backlash for organising the tournament with an audience amid the pandemic.
The charismatic 18-year-old Canadian has infatuated the New York crowds with his skill and on court panache that has made him the youngest man to make it into the fourth round of the US Open since American Michael Chang in 1989.
It was a repeat of the 34-year-old's straight sets victory over Andy Murray in the second round of the US Open in August.
Verdasco questions French Open COVID-19 testing protocols after withdrawal
Roger Federer made a comfortable start to his quest for a 100th title, despatching Fabio Fognini in straight sets to ease into the quarter-finals at the Paris Masters on Thursday.
Top seed Simona Halep came back from 4-1 down in the deciding set to beat Elina Svitolina 6-3 3-6 6-4 in the Qatar Open semi-final on Friday, marking her first victory over the Ukrainian in nearly two years.
Roger Federer does not fret about who umpires his matches and said on Wednesday all players should be treated equally by officials, whatever their ranking.
Images from the third day at the US Open, the final Grand Slam tournament of the year, in New York, on Wednesday:
Roger Federer avoided any more security scares as he moved smoothly into the third round of the French Open on Wednesday but danger still lurks in the bottom half of the draw, namely in the shape of Japan's Kei Nishikori.
Photos from the matches played at the Miami Open on Tuesday
Nadal needed all his experience to keep Pouille at bay in the decider and the match looked to be heading for another tiebreak before he pounced to break Pouille's serve for the first time to go 6-5 up in the third.
Tennis fans expressed frustration that the players weren't getting better crowds.
Images from matches played on Day 5 at the Australian Open in Melbourne Park on Friday
Roger Federer suffered a shock 3-6, 6-3, 7-6(4) defeat to Australian wildcard Thanasi Kokkinakis on Saturday that will cost the Swiss his world number one ranking and leaves the Miami men's tournament wide open.
A summary of sports events and sports persons, who made news on Monday
Polish fifth seed Agnieszka Radwanska was the highest women's casualty at the Miami Open on Saturday, blown away for the second time this year by Croatian Mirjana Lucic-Baroni.
Images from Day 1 of the US Open in New York, on Monday.
It was the Russian's first competitive match since she withdrew from the St Petersburg Open in January.
Earlier on Wednesday, Czech Karolina Pliskova was forced to withdraw from the tournament due to a viral illness.
Milos Raonic overcame third seed Grigor Dimitrov 7-5, 3-6, 6-3 to reach the third round at the Madrid Open on Tuesday and set up an all-Canadian clash with teenager Denis Shapovalov.
Former world number one Garbine Muguruza was beaten 7-5, 6-4 by Aryna Sabalenka in the China Open second round on Tuesday while an ailing Jelena Ostapenko lost 6-0, 6-0 to Wang Qiang.
IMAGES from matches played on Day 4 of the French Open at Roland Garros on Wednesday
Karolina Pliskova lost her cool over a line call and bashed a hole into the umpire's chair with her racket after suffering a 3-6, 6-3, 7-5 defeat by Maria Sakkari in the Italian Open second round on Wednesday.
IMAGES from matches on Day 8 at the French Open
Images from the Australian Open matches played at Melbourne Park on Wednesday.
Former world number one Andy Murray withdrew from the Brisbane International with a hip problem on Tuesday, further putting in doubt the Briton's prospects of being fit in time for the Australian Open later this month.